Comparative hemorheology, in Handbook of Hemorheology and Hemodynamics, eds. O. K. Baskurt, M. R. Hardeman, M. W. Rampling, and. Article · January. Handbook of Hemorheology and Hemodynamics – Ebook download as PDF File .pdf), Text File .txt) or read book online. significantly contribute to hemorheological variations in diseases and in certain extreme physiological properties. KEYWORDS: Hemorheology, hemodynamics, viscosity, erythrocyte deformability, Handbook of Engineering. New York.

Author: Shazil Tumi
Country: Cyprus
Language: English (Spanish)
Genre: Photos
Published (Last): 23 June 2015
Pages: 475
PDF File Size: 11.77 Mb
ePub File Size: 20.13 Mb
ISBN: 943-2-24262-277-1
Downloads: 82189
Price: Free* [*Free Regsitration Required]
Uploader: Duzil

However, polymer depletion as a mechanism for red blood hanrbook aggregation has received much less attention, with only a few literature reports relevant to this approach [24, ].

In blood, fibrinogen hemodynajics one of the most important hwmodynamics of blood viscosity due to its strong tendency to increase both plasma viscosity and RBC aggregation [17]. Clearly, there are interesting parallels but important distinctions between the behaviors of the two cell types.

Circulating leukocytes and platelets must adhere to the wall of blood vessels in order to carry out the protective function of immunity for leukocytes and hemostasis for platelets: The elastic deformability of cells means that energy can be stored in and recovered from cell deformation. The viscoelasticity of blood has a direct effect on the propagation of the pulse throughout the arterial system [1].

Leukocyte adhesion is mainly restricted to post capillary venules where shear rates and stresses are relatively low. The development of the fetus, the transition and adaptation at birth, and the subsequent maturation during infancy and childhood require considerable adaptation processes of the macro- and microcirculation.

Viscoelasticity of Human Blood.

There has been a handvook change in our understanding of the factors that determine the degree of RBC aggregation: They have successfully achieved their objective to publish a well-written and well-edited handbook that will be valuable for researchers and students in the field.

In selecting topics for the present handbook the editors have attempted to provide a general overview of both basic science and clinical hemorheology and hemodynamics.

Here we review basic concepts of dynamic cellular adhesion and experimental approaches to their investigation that are largely common between the platelets and leukocytes.

To understand the structure-function relationships of red blood cells RBC together with associated physiological mechanisms, comparative studies are still a classical approach. Although damage to platelets and WBC is an extremely important topic, this chapter concentrates on the mechanical trauma to RBC and related changes in rheological properties of whole blood. In addition, some information on developmental hemorheology during infancy and childhood will also be presented.

Moreover, the neonate is at high risk to acquire disorders with strong impact on blood circulation e. Rampling Limited preview – Prosthetic heart valves, heart-assist devices, oxygenators, dialyzers and other biomedical devices that repair, replace or support various organ systems of the human body are in wide clinical use.


Description This publication primarily focuses on the macro- and micro-rheological behavior of blood and its formed elements, on interactions between the formed elements and blood vessel walls, and on the microvascular aspects of hemodynamics.

Normal human blood contains a high concentration of red blood cells RBCwhich are elastic elements. These classifications, based on the mechanisms of hemorheological alterations, need to be revised in light of developments in the past twenty years. Blood flows only because the RBC are deformable and can be reoriented to slide on the low viscosity plasma.

Abstract The factors that determine the rheological behavior of blood, a two-phase fluid, include the relative volume of each phase as reflected by the hematocrit value, plasma composition and the properties of cellular elements.

Abstract Over the last 30 years significant progress has been made in the fields of hemodynamics and hemorheology, spurred on by innovative developments in measurement techniques [1] and instrumentation [].

Their slow motion through blood capillaries was recognized early and modern interest in their rheological behavior was spurred by the observations of deformation in human microvessels and glass capillaries made by Bagge, Branemark, Skalak and colleagues []. This publication is not primarily famous for this description of the shear rate dependence of blood viscosity, but rather because it pointed out that measurements of blood viscosity in cylindrical tubes could not be used to predict its effects on in vivo blood flow [1].

Over the last 30 years significant progress has been made in the fields of hemodynamics and hemorheology, spurred on by innovative developments in measurement techniques [1] and instrumentation [].

Measurements obtained via these methods have been used for monitoring hemodynamic phenomena and diagnosing circulatory disorders, thus providing a deeper understanding of hemodynamic-related diseases in humans [4].

Whittaker and Winton compared the apparent viscosity of blood under a constant pressure difference as determined by simultaneously measuring flow through a dog hind limb preparation and a glass viscometer arranged in parallel.

IOS Press Ebooks – Handbook of Hemorheology and Hemodynamics

The linkage between the in vitro and in vivo research described in the book will be of interest to both basic science and clinical investigators. However, special instruments developed in the last few decades and dedicated to the measurement of various hemorheological parameters e. This early understanding of blood rheology that dominated the first several decades of 20 th century was clearly described in the famous publication of Whittaker and Winton [1]. This chapter gives an overview of the composition of normal adult human blood and some indication of the ways in which it can be altered in diseased states.


Such transfusions are given in response to severe anemia, significant blood loss, or as therapy e. Table 1 presents a classification of hemorheological alterations based upon the considerations described above.

In this chapter, we review the structure-function relationships that determine the mechanical and adhesive properties of RBC and describe some techniques and methods, old and new, for quantifying these important rheological properties. Peculiar rheologic properties of blood appear to play an important role in the maintenance of high blood flow conditions in spite of very low blood pressure in the fetus and neonate [1]. In contrast, the depletion hemofheology proposes quite the opposite.

Ebook: Handbook of Hemorheology and Hemodynamics

In turn, these stimuli trigger a response that is mediated by the release of a number of autocrine and paracrine substances. Since many aspects of hemorheology and hemodynamics are affected by disease or clinical states, these effects are discussed as are hyperviscosity syndromes, therapy for disturbed blood rheology, and methods in hemorheology and hemodynamics.

In the bridging model, red cell aggregation is proposed to occur when the bridging forces due to the adsorption of macromolecules onto adjacent cell surfaces exceed disaggregating forces due to electrostatic repulsion, membrane strain and mechanical shearing [15, ]. In selecting topics for this handbook the editors have attempted to provide a general overview of both basic science and clinical hemorheology and hemodynamics. Similar approaches have been used by others [2].

It is necessary to know that the hemorheological profile of an animal cannot be judged by a single rheological value, but must be considered as part of the cardiovascular hemodyna,ics in which the blood is flowing. A welcome feature of the handbook is that it includes a chapter on comparative hemorheology, showing that the rheological properties of red cells vary widely among the animal species, thus shedding light on the process of adaptation to a specific environment or lifestyle, and a chapter on neonatal and fetal blood rheology showing the considerable adaptation processes in play at birth and in infancy and childhood.

Meiselman hematocrit hemodilution hemodynamics hemoglobin hemolysis Hemorheol hemorheological parameters human hyperviscosity impaired increased interactions ischemia ischemic layer leukocytes levels Linderkamp low shear measured mechanical properties Microcirc microcirculation microcirculatory microvascular microvessels mPa.

For example, myogenic or adrenergic tone are endothelium-independent, yet vascular homeostasis is controlled by a balanced release of endothelium-derived bioactive factors. My library Hemodnyamics Advanced Book Search.