A collection of disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Hyperkeratosis lenticularis . Flegel disease is also known as ‘hyperkeratosis lenticularis perstans’. It was first described by Flegel in It is characterised by red-brown papules with. Hyperkeratosis lenticularis perstans (HLP) is a rare cutaneous disorder occurring in older persons and manifested by multiple benign pink to reddish-brown.

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Flegel disease is a rare dermatosis characterized by asymptomatic hyperkeratotic papules predominantly on the dorsa of the feet and lower legs.

Clinical input is often very helpful in making a diagnosis histopathologically. The disorder is thought to be caused by alterations in the membrane-coating granules lamellar granulesOdland bodies of the keratinocytes.

In Flegel disease, sections show discrete zones of compact lamellar hyperkeratosis with focal parakeratosis figure 1. The epidermis under the hyperkeratosis is atrophic compared with the surrounding skin, and the granular layer is attenuated absent figure 2.


Flegel disease pathology

The papillary dermis contains a dense band-like infiltrate composed of small lymphocytes intermingled with histiocytes. Vasodilation of superficial vessels is also seen figure 3. None are generally needed.

Examination of hyperkeratsois membrane-coating granules by electon microscopy is commonly reported in the literature but is not considered useful for the diagnosis. Kyrle disease — This condition is clinically similar and may share some pathogenic components.

Flegel disease | DermNet NZ

Kyrle disease should exhibit an impressive keratin plug and inflammatory material perforating through the epidermis. Porokeratosis — Cornoid lamellae allow easy diagnosis lneticularis this condition. Actinic keratosis — Actinic dysplasia is seen. Some authors believe Flegel disease is a form of incipient epidermal dysplasia. Self-skin examination New smartphone apps to check your skin Learn more Sponsored content.

DermNet NZ does not provide an online consultation service. If you have any concerns with your skin or its treatment, see a dermatologist for advice. Histopathological differences between early and old lesions of hyperkeratosis Lenticularis Perstans Hyperkeratozis disease. Dermatopathology glossary Flegel disease Dermatopathology index Books about skin diseases: See the DermNet NZ bookstore.